|Application ||WB, E|
|Calculated MW||44593 Da|
|Antigen Region||1-30 aa|
|Other Names||Immunoglobulin superfamily member 5, IgSF5, Junctional adhesion molecule 4, JAM-4, IGSF5, JAM4|
|Target/Specificity||This IGSF5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human IGSF5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IGSF5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells- Sertoli cells (By similarity).|
|Cellular Location||Cell membrane; Single-pass membrane protein. Cell junction, tight junction|
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Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity).
Rose, J. Phd, et al. Mol. Med. (2010) In press :
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