|Application ||WB, E|
|Other Accession||NP_001153059.1, NP_001153060.1, NP_598000.2|
|Calculated MW||161689 Da|
|Antigen Region||82-109 aa|
|Other Names||CD109 antigen, 150 kDa TGF-beta-1-binding protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7, Platelet-specific Gov antigen, p180, r150, CD109, CD109, CPAMD7|
|Target/Specificity||This CD109 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-109 amino acids from the N-terminal region of human CD109.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD109 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates negatively TGFB1 signaling in keratinocytes.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 4 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta|
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Provided below are standard protocols that you may find useful for product applications.
CD109 is a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta).
Nie, Y.M., et al. Transfus Med 20(6):376-382(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Hagiwara, S., et al. Oncogene 29(15):2181-2191(2010)
Bhatti, F.A., et al. Transfus Med 20(2):78-87(2010)
Raychaudhuri, S., et al. Nat. Genet. 41(12):1313-1318(2009)
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