|Application ||WB, E|
|Other Accession||NP_001153059.1, NP_001153060.1, NP_598000.2|
|Calculated MW||161689 Da|
|Antigen Region||82-109 aa|
|Other Names||CD109 antigen, 150 kDa TGF-beta-1-binding protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7, Platelet-specific Gov antigen, p180, r150, CD109, CD109, CPAMD7|
|Target/Specificity||This CD109 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-109 amino acids from the N-terminal region of human CD109.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD109 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates negatively TGFB1 signaling in keratinocytes.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 4 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CD109 is a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta).
Nie, Y.M., et al. Transfus Med 20(6):376-382(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Hagiwara, S., et al. Oncogene 29(15):2181-2191(2010)
Bhatti, F.A., et al. Transfus Med 20(2):78-87(2010)
Raychaudhuri, S., et al. Nat. Genet. 41(12):1313-1318(2009)
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