|Application ||WB, E|
|Calculated MW||25686 Da|
|Antigen Region||41-69 aa|
|Other Names||DnaJ homolog subfamily B member 8, DNAJB8|
|Target/Specificity||This DNAJB8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human DNAJB8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DNAJB8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.|
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Provided below are standard protocols that you may find useful for product applications.
DNAJB8 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM].
Hageman, J., et al. Mol. Cell 37(3):355-369(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Ohtsuka, K., et al. Cell Stress Chaperones 5(2):98-112(2000)
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