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CPLX3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8WVH0 |
| Other Accession | Q8R1B5, Q0IIE0, NP_001025176.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17557 Da |
| Antigen Region | 52-81 aa |
| Gene ID | 594855 |
|---|---|
| Other Names | Complexin-3, Complexin III, CPX III, CPLX3 |
| Target/Specificity | This CPLX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-81 amino acids from the Central region of human CPLX3. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CPLX3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CPLX3 |
|---|---|
| Function | Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). |
| Cellular Location | Synapse {ECO:0000250|UniProtKB:Q8R1B5}. Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q8R1B5}. Note=Enriched at the synaptic terminal (By similarity). Localized at glycinergic synaptic contacts of AII amacrine cells with OFF cone bipolar cells in the OFF sublamina of the retina inner nuclear layer (By similarity) {ECO:0000250|UniProtKB:Q8R1B5} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Positively regulates a late step in synaptic vesicle exocytosis (By similarity).
References
Newton-Cheh, C., et al. Nat. Genet. (2009) In press :
Levy, D., et al. Nat. Genet. (2009) In press :
Reim, K., et al. J. Cell Biol. 169(4):669-680(2005)
Ohira, M., et al. Oncogene 22(35):5525-5536(2003)
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