ZUFSP Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q96AP4 |
Other Accession | Q4R4A2, NP_659499.2 |
Reactivity | Human, Hamster, Mouse |
Predicted | Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 65959 Da |
Antigen Region | 107-136 aa |
Gene ID | 221302 |
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Other Names | Zinc finger with UFM1-specific peptidase domain protein, ZUFSP, C6orf113 |
Target/Specificity | This ZUFSP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human ZUFSP. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZUFSP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZUP1 (HGNC:21224) |
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Function | Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains (PubMed:29576528, PubMed:29563501, PubMed:29476094). Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage (PubMed:29576528, PubMed:29576527). Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress (PubMed:29563501). |
Cellular Location | Cytoplasm. Nucleus. Note=Mostly present in the nuclear fraction. Localizes to DNA lesions. |
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Provided below are standard protocols that you may find useful for product applications.
References
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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