|Application ||WB, FC, E|
|Calculated MW||40716 Da|
|Antigen Region||185-212 aa|
|Other Names||Hematopoietic progenitor cell antigen CD34, CD34, CD34|
|Target/Specificity||This CD34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-212 amino acids from the Central region of human CD34.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD34 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues|
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Provided below are standard protocols that you may find useful for product applications.
CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.
Eijgelsheim, M., et al. Hum. Mol. Genet. 19(19):3885-3894(2010)
McCalmont, T.H., et al. J. Cutan. Pathol. 37 (9), 923 (2010) :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Cho, S.Y., et al. Cancer Res. 70(8):3402-3410(2010)
Gluhovschi, C., et al. Folia Histochem. Cytobiol. 48(2):230-236(2010)
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