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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CHRDL1 Antibody (N-term)   

CHRDL1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CHRDL1 Antibody (N-term) AP10667a
    CHRDL1 Antibody (N-term) (Cat. #AP10667a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CHRDL1 antibody detected the CHRDL1 protein (arrow).
  • IHC-P - CHRDL1 Antibody (N-term) AP10667a
    CHRDL1 antibody (N-term) (Cat. #AP10667a) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CHRDL1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BU40
Other Accession NP_660277
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51168 Da
Antigen Region 2-30 aa
Additional Information
Gene ID 91851
Other Names Chordin-like protein 1, Neuralin-1, Neurogenesin-1, Ventroptin, CHRDL1, NRLN1
Target/Specificity This CHRDL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human CHRDL1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCHRDL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NRLN1
Function Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.
Cellular Location Secreted.
Tissue Location Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes
Research Areas
Citations (0)

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CHRDL1 is an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described.


Fernandes, H., et al. Cells Tissues Organs (Print) 191(6):443-452(2010)
Larman, B.W., et al. J. Am. Soc. Nephrol. 20(5):1020-1031(2009)
Kane, R., et al. Mol. Vis. 14, 1138-1148 (2008) :
Kosinski, C., et al. Proc. Natl. Acad. Sci. U.S.A. 104(39):15418-15423(2007)
Gazzerro, E., et al. Rev Endocr Metab Disord 7 (1-2), 51-65 (2006) :

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$ 295.00
$ 99.00
Cat# AP10667a
(40 western blots)
Availability: In Stock
Bulk Size
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