|Application ||WB, IHC-P, E|
|Calculated MW||51168 Da|
|Antigen Region||2-30 aa|
|Other Names||Chordin-like protein 1, Neuralin-1, Neurogenesin-1, Ventroptin, CHRDL1, NRLN1|
|Target/Specificity||This CHRDL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human CHRDL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHRDL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.|
|Tissue Location||Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes|
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Provided below are standard protocols that you may find useful for product applications.
CHRDL1 is an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described.
Fernandes, H., et al. Cells Tissues Organs (Print) 191(6):443-452(2010)
Larman, B.W., et al. J. Am. Soc. Nephrol. 20(5):1020-1031(2009)
Kane, R., et al. Mol. Vis. 14, 1138-1148 (2008) :
Kosinski, C., et al. Proc. Natl. Acad. Sci. U.S.A. 104(39):15418-15423(2007)
Gazzerro, E., et al. Rev Endocr Metab Disord 7 (1-2), 51-65 (2006) :
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