|Application ||WB, IHC-P, E|
|Other Accession||Q13449, NP_001630.1|
|Calculated MW||25387 Da|
|Antigen Region||151-178 aa|
|Other Names||Serum amyloid P-component, SAP, 95S alpha-1-glycoprotein, Serum amyloid P-component(1-203), APCS, PTX2|
|Target/Specificity||This APCS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-178 amino acids from the C-terminal region of human APCS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APCS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.|
|Tissue Location||Found in serum and urine.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
Song, Z., et al. Atherosclerosis 211(1):90-95(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Lu, J., et al. Nature 456(7224):989-992(2008)
Verwey, N.A., et al. Dement Geriatr Cogn Disord 26(6):522-527(2008)
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