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COL18A1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - COL18A1 Antibody (Center) AP10706c
    COL18A1 Antibody (Center) (Cat. #AP10706c) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the COL18A1 antibody detected the COL18A1 protein (arrow).
  • IHC-P - COL18A1 Antibody (Center) AP10706c
    COL18A1 Antibody (Center) (Cat. #AP10706c) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the COL18A1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P39060
Other Accession NP_085059.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 178188 Da
Antigen Region 1311-1339 aa
Additional Information
Gene ID 80781
Other Names Collagen alpha-1(XVIII) chain, Endostatin, COL18A1
Target/Specificity This COL18A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1311-1339 amino acids from the Central region of human COL18A1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCOL18A1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COL18A1
Function COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Present in multiple organs with highest levels in liver, lung and kidney
Research Areas
Citations (0)

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COL18A1 is the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure.


Hamano, Y., et al. J. Am. Soc. Nephrol. 21(9):1445-1455(2010)
Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)
Lee, K.S., et al. Tumour Biol. 31(3):165-170(2010)
Faye, C., et al. Biochem. J. 427(3):467-475(2010)
Polikarpova, S.B., et al. Bull. Exp. Biol. Med. 148(4):634-637(2009)

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Cat# AP10706c
(40 western blots)
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