|Application ||WB, E|
|Other Accession||Q9YH90, NP_067018.2|
|Calculated MW||23292 Da|
|Antigen Region||130-159 aa|
|Other Names||Claudin-6, Skullin, CLDN6|
|Target/Specificity||This CLDN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human CLDN6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLDN6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity). May act as a coreceptor for HCV entry into hepatic cells.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
Wu, Q., et al. Eur. J. Cancer Prev. 19(3):186-194(2010)
Kleinschmidt-DeMasters, B.K., et al. Am. J. Surg. Pathol. 34(3):341-354(2010)
Rendon-Huerta, E., et al. J Gastrointest Cancer 41(1):52-59(2010)
Wu, Q., et al. Zhonghua Yi Xue Za Zhi 90(6):407-412(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
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