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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   COX10 Antibody (C-term)   

COX10 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - COX10 Antibody (C-term) AP10714b
    COX10 Antibody (C-term) (Cat. #AP10714b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the COX10 antibody detected the COX10 protein (arrow).
  • IHC-P - COX10 Antibody (C-term) AP10714b
    COX10 antibody (C-term) (Cat. #AP10714b) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the COX10 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - COX10 Antibody (C-term) AP10714b
    COX10 Antibody (C-term) (Cat. #AP10714b) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q12887
Other Accession NP_001294.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48910 Da
Antigen Region 383-410 aa
Additional Information
Gene ID 1352
Other Names Protoheme IX farnesyltransferase, mitochondrial, 251-, Heme O synthase, COX10
Target/Specificity This COX10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-410 amino acids from the C-terminal region of human COX10.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCOX10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COX10
Function Converts protoheme IX and farnesyl diphosphate to heme O.
Cellular Location Mitochondrion membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.


Chen, Z., et al. Oncogene 29(30):4362-4368(2010)
Vitali, M., et al. J Neural Transm 116(12):1635-1641(2009)
Dassa, E.P., et al. EMBO Mol Med 1(1):30-36(2009)
Veluthakal, R., et al. Diabetes 56(1):204-210(2007)
Coenen, M.J., et al. Ann. Neurol. 56(4):560-564(2004)

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$ 295.00
$ 99.00
Cat# AP10714b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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