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ESCO2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ESCO2 Antibody (Center) AP10717c
    ESCO2 Antibody (Center) (Cat. #AP10717c) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the ESCO2 antibody detected the ESCO2 protein (arrow).
  • FC - ESCO2 Antibody (Center) AP10717c
    ESCO2 Antibody (Center) (Cat. #AP10717c) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q56NI9
Other Accession NP_001017420.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68307 Da
Antigen Region 132-161 aa
Additional Information
Gene ID 157570
Other Names N-acetyltransferase ESCO2, 231-, Establishment of cohesion 1 homolog 2, ECO1 homolog 2, ESCO2
Target/Specificity This ESCO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-161 amino acids from the Central region of human ESCO2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsESCO2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ESCO2
Function Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3.
Cellular Location Nucleus. Chromosome
Tissue Location Widely expressed in fetal tissues. In adult, it is expressed in thymus, placenta and small intestine
Research Areas
Citations (0)

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This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Nishihara, M., et al. Biochem. Biophys. Res. Commun. 393(1):111-117(2010)
Vega, H., et al. J. Med. Genet. 47(1):30-37(2010)
Terret, M.E., et al. Nature 462(7270):231-234(2009)
van der Lelij, P., et al. PLoS ONE 4 (9), E6936 (2009) :

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Cat# AP10717c
(40 western blots)
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