|Application ||WB, FC, E|
|Calculated MW||68307 Da|
|Antigen Region||132-161 aa|
|Other Names||N-acetyltransferase ESCO2, 231-, Establishment of cohesion 1 homolog 2, ECO1 homolog 2, ESCO2|
|Target/Specificity||This ESCO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-161 amino acids from the Central region of human ESCO2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ESCO2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3.|
|Cellular Location||Nucleus. Chromosome|
|Tissue Location||Widely expressed in fetal tissues. In adult, it is expressed in thymus, placenta and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Nishihara, M., et al. Biochem. Biophys. Res. Commun. 393(1):111-117(2010)
Vega, H., et al. J. Med. Genet. 47(1):30-37(2010)
Terret, M.E., et al. Nature 462(7270):231-234(2009)
van der Lelij, P., et al. PLoS ONE 4 (9), E6936 (2009) :
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