|Application ||WB, IHC-P, E|
|Other Accession||Q925N6, Q7TQA1, NP_001164433.1|
|Calculated MW||148936 Da|
|Antigen Region||1270-1297 aa|
|Other Names||Immunoglobulin superfamily member 1, IgSF1, Immunoglobulin-like domain-containing protein 1, Inhibin-binding protein, InhBP, Pituitary gland-specific factor 2, p120, IGSF1, IGDC1, KIAA0364, PGSF2|
|Target/Specificity||This IGSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1270-1297 amino acids from the C-terminal region of human IGSF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IGSF1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IGDC1, KIAA0364, PGSF2|
|Function||Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription.|
|Cellular Location||Isoform 1: Membrane; Multi- pass membrane protein Isoform 3: Secreted.|
|Tissue Location||Highly expressed in pancreas, testis and fetal liver. Moderately expressed in heart, prostate and small intestine. Expressed at very low levels in brain, thymus, ovary, colon, fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pituitary gland.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. Multiple transcript variants encoding different isoforms have been found for this gene.
Robakis, T., et al. J. Biol. Chem. 283(52):36369-36376(2008)
Nakayama, M., et al. Genome Res. 12(11):1773-1784(2002)
Tanaka, S., et al. J. Mol. Endocrinol. 28(1):33-44(2002)
Gui, Y., et al. J. Clin. Endocrinol. Metab. 86(5):2104-2110(2001)
Chapman, S.C., et al. Mol. Endocrinol. 15(4):668-679(2001)
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