|Application ||WB, FC, E|
|Calculated MW||35541 Da|
|Antigen Region||72-100 aa|
|Other Names||Protein SEC13 homolog, SEC13-like protein 1, SEC13-related protein, SEC13, D3S1231E, SEC13L1, SEC13R|
|Target/Specificity||This SEC13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-100 amino acids from the Central region of human SEC13.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEC13 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||D3S1231E, SEC13L1, SEC13R|
|Function||Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.|
|Cellular Location||Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=In interphase, localizes at both sides of the NPC|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found.
Nielsen, A.L. Biochem. Biophys. Res. Commun. 388(3):571-575(2009)
Townley, A.K., et al. J. Cell. Sci. 121 (PT 18), 3025-3034 (2008) :
Stagg, S.M., et al. Cell 134(3):474-484(2008)
Hsia, K.C., et al. Cell 131(7):1313-1326(2007)
Glavy, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 104(10):3811-3816(2007)
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