- CITATIONS: 3
|Application ||WB, E|
|Other Accession||Q6QI25, Q9CPZ6, Q5XJR6, Q0VD15, Q9CQZ0, Q53FV1, Q5E972, Q5XH57, Q9P0S3, Q8JFB7, Q29RQ9, NP_644809.1|
|Predicted||Rat, Zebrafish, Xenopus, Bovine|
|Calculated MW||17495 Da|
|Antigen Region||53-81 aa|
|Other Names||ORM1-like protein 3, ORMDL3|
|Target/Specificity||This ORMDL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 amino acids from the Central region of human ORMDL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ORMDL3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein|
|Tissue Location||Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus|
Provided below are standard protocols that you may find useful for product applications.
Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010) Liu, X., et al. Nat. Genet. 42(8):658-660(2010) Halapi, E., et al. Eur. J. Hum. Genet. 18(8):902-908(2010) Dobbins, S.E., et al. Int. J. Cancer (2010) In press : McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
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