|Application ||WB, E|
|Other Accession||Q91ZE0, Q0VC74, NP_060666.1|
|Calculated MW||49518 Da|
|Antigen Region||120-149 aa|
|Other Names||Trimethyllysine dioxygenase, mitochondrial, Epsilon-trimethyllysine 2-oxoglutarate dioxygenase, Epsilon-trimethyllysine hydroxylase, TML hydroxylase, TML-alpha-ketoglutarate dioxygenase, TML dioxygenase, TMLD, TMLHE, TMLH|
|Target/Specificity||This TMLHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the N-terminal region of human TMLHE.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TMLHE Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (PubMed:11431483, PubMed:23092983).|
|Cellular Location||Mitochondrion matrix|
|Tissue Location||All isoforms, but isoform 8, are widely expressed in adult and fetal tissues. Isoform 8 is restricted to heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded protein converts trimethyllysine into hydroxytrimethyllysine. A pseudogene of this gene is found on chromosome X. Alternate splicing results in multiple transcript variants.
Monfregola, J., et al. Gene 395 (1-2), 86-97 (2007) :
Monfregola, J., et al. J. Cell. Physiol. 204(3):839-847(2005)
Vaz, F.M., et al. J. Biol. Chem. 276(36):33512-33517(2001)
Rogner, U.C., et al. Genome Res. 6(10):922-934(1996)
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