|Application ||WB, IHC-P, E|
|Calculated MW||29481 Da|
|Antigen Region||10-36 aa|
|Other Names||Ribonuclease T2, 3127-, Ribonuclease 6, RNASET2, RNASE6PL|
|Target/Specificity||This RNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-36 amino acids from the N-terminal region of human RNT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNT2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.|
|Cellular Location||Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction|
|Tissue Location||Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.
Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)
Quan, C., et al. Nat. Genet. 42(7):614-618(2010)
Liu, J., et al. J. Cell. Mol. Med. 14(5):1146-1155(2010)
Henneke, M., et al. Nat. Genet. 41(7):773-775(2009)
Monti, L., et al. Oncol. Res. 17(2):69-74(2008)
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