CORO7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | P57737 |
Other Accession | NP_078811.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 100605 Da |
Antigen Region | 173-202 aa |
Gene ID | 79585 |
---|---|
Other Names | Coronin-7, Crn7, 70 kDa WD repeat tumor rejection antigen homolog, CORO7 |
Target/Specificity | This CORO7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the N-terminal region of human CORO7. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CORO7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CORO7 |
---|---|
Function | F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. |
Cellular Location | Golgi apparatus membrane. Golgi apparatus, trans- Golgi network. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments |
Tissue Location | Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine |
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Provided below are standard protocols that you may find useful for product applications.
Background
Coronins, such as CORO7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins. CORO7 plays a role in Golgi complex morphology and function (Rybakin et al., 2004, 2006 [PubMed 15327992] [PubMed 16905771]).
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Rybakin, V., et al. Cell. Mol. Life Sci. 65(15):2419-2430(2008)
Rybakin, V., et al. J. Biol. Chem. 281(41):31070-31078(2006)
Rybakin, V., et al. FEBS Lett. 573 (1-3), 161-167 (2004) :
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