- CITATIONS: 2
|Application ||WB, E|
|Calculated MW||32742 Da|
|Antigen Region||218-248 aa|
|Other Names||Glycine N-methyltransferase, GNMT|
|Target/Specificity||This GNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-248 amino acids from the C-terminal region of human GNMT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNMT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.|
|Tissue Location||Abundant in liver.|
Provided below are standard protocols that you may find useful for product applications.
Glycine N-methyltransferase catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine (AdoHcy) and participates in the detoxification pathway in liver cells.
Augoustides-Savvopoulou, P., et al., J. Inherit. Metab. Dis. 26(8):745-759 (2003). Tseng, T.L., et al., Cancer Res. 63(3):647-654 (2003). Luka, Z., et al., Hum. Genet. 110(1):68-74 (2002). Strausberg RL, et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Mudd, S.H., et al., J. Inherit. Metab. Dis. 24(4):448-464 (2001).
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