|Application ||WB, IHC-P, FC, E|
|Calculated MW||43590 Da|
|Antigen Region||335-363 aa|
|Other Names||Reticulon-4-interacting protein 1, mitochondrial, NOGO-interacting mitochondrial protein, RTN4IP1, NIMP|
|Target/Specificity||This RT4I1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 amino acids from the C-terminal region of human RT4I1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RT4I1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.|
|Cellular Location||Mitochondrion outer membrane Note=Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria|
|Tissue Location||Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a novel mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. The interaction of reticulon 4 with mitochondrial proteins may provide insight into the mechanisms for reticulon-induced inhibition of neurite growth.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Domeniconi, M., et al. Neuron 35(2):283-290(2002)
Hu, W.H., et al. J. Neurochem. 81(1):36-45(2002)
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