RT4I1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q8WWV3 |
Other Accession | NP_116119.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 43590 Da |
Antigen Region | 335-363 aa |
Gene ID | 84816 |
---|---|
Other Names | Reticulon-4-interacting protein 1, mitochondrial, NOGO-interacting mitochondrial protein, RTN4IP1, NIMP |
Target/Specificity | This RT4I1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 amino acids from the C-terminal region of human RT4I1. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RT4I1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RTN4IP1 |
---|---|
Synonyms | NIMP |
Function | Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury. |
Cellular Location | Mitochondrion outer membrane Note=Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria |
Tissue Location | Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a novel mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. The interaction of reticulon 4 with mitochondrial proteins may provide insight into the mechanisms for reticulon-induced inhibition of neurite growth.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Domeniconi, M., et al. Neuron 35(2):283-290(2002)
Hu, W.H., et al. J. Neurochem. 81(1):36-45(2002)
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