|Application ||WB, FC, E|
|Other Accession||P98199, NP_001005855.1|
|Calculated MW||137440 Da|
|Antigen Region||18-47 aa|
|Other Names||Phospholipid-transporting ATPase ID, ATPase class I type 8B member 2, P4-ATPase flippase complex alpha subunit ATP8B2, ATP8B2, ATPID, KIAA1137|
|Target/Specificity||This AT8B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human AT8B2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AT8B2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane. Note=TMEM30A, but not TMEM30B, is required for its export from ER to the plasma membrane|
|Tissue Location||Isoform 3 is ubiquitous, with highest expression in aorta, cerebellum and uterus|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Harris, M.J., et al. Biochim. Biophys. Acta 1633(2):127-131(2003)
Halleck, M.S., et al. Physiol. Genomics 1(3):139-150(1999)
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