CB086 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | O95876 |
Other Accession | NP_056994.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 85084 Da |
Antigen Region | 676-705 aa |
Gene ID | 51057 |
---|---|
Other Names | WD repeat-containing and planar cell polarity effector protein fritz homolog, hFRTZ, Bardet-Biedl syndrome 15 protein, WD repeat-containing and planar cell polarity effector protein, WDPCP, BBS15, C2orf86, FRITZ |
Target/Specificity | This CB086 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 676-705 amino acids from the C-terminal region of human CB086. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CB086 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | WDPCP |
---|---|
Synonyms | BBS15, C2orf86, FRITZ |
Function | Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q32NR9}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q32NR9} Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q32NR9} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The C2ORF86 gene encodes an ortholog of Drosophila 'fritz,' a cytoplasmic WD40 repeat protein that controls planar cell polarity (summarized by Kim et al., 2010 [PubMed 20671153]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kim, S.K., et al. Science 329(5997):1337-1340(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
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