|Application ||WB, IHC-P, E|
|Calculated MW||85084 Da|
|Antigen Region||676-705 aa|
|Other Names||WD repeat-containing and planar cell polarity effector protein fritz homolog, hFRTZ, Bardet-Biedl syndrome 15 protein, WD repeat-containing and planar cell polarity effector protein, WDPCP, BBS15, C2orf86, FRITZ|
|Target/Specificity||This CB086 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 676-705 amino acids from the C-terminal region of human CB086.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CB086 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BBS15, C2orf86, FRITZ|
|Function||Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements.|
|Cellular Location||Cell membrane. Cytoplasm, cytoskeleton, cilium axoneme|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The C2ORF86 gene encodes an ortholog of Drosophila 'fritz,' a cytoplasmic WD40 repeat protein that controls planar cell polarity (summarized by Kim et al., 2010 [PubMed 20671153]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kim, S.K., et al. Science 329(5997):1337-1340(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
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