|Application ||WB, IHC-P, FC, E|
|Calculated MW||29763 Da|
|Antigen Region||232-261 aa|
|Other Names||Metaxin-2, Mitochondrial outer membrane import complex protein 2, MTX2|
|Target/Specificity||This MTX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-261 amino acids from the C-terminal region of human MTX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MTX2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in transport of proteins into the mitochondrion.|
|Cellular Location||Mitochondrion outer membrane|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Xie, J., et al. FEBS Lett. 581(18):3545-3549(2007)
Kozjak-Pavlovic, V., et al. EMBO Rep. 8(6):576-582(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Armstrong, L.C., et al. J. Cell. Biochem. 74(1):11-22(1999)
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