SYNCI Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q9H7C4 |
Other Accession | NP_110413.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 55299 Da |
Antigen Region | 129-158 aa |
Gene ID | 81493 |
---|---|
Other Names | Syncoilin, Syncoilin intermediate filament 1, Syncoilin-1, SYNC, SYNC1 |
Target/Specificity | This SYNCI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-158 amino acids from the N-terminal region of human SYNCI. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SYNCI Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SYNC |
---|---|
Synonyms | SYNC1 |
Function | Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. |
Cellular Location | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9EPM5}. Note=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern (By similarity) {ECO:0000250|UniProtKB:Q9EPM5} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Wakayama, Y., et al. Int. J. Neurosci. 120(2):144-149(2010)
Jordanova, A., et al. Nat. Genet. 38(2):197-202(2006)
Brown, S.C., et al. Muscle Nerve 32(6):715-725(2005)
Poon, E., et al. J. Biol. Chem. 277(5):3433-3439(2002)
Newey, S.E., et al. J. Biol. Chem. 276(9):6645-6655(2001)
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