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ORML2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q53FV1 |
| Other Accession | Q6QI25, Q9CPZ6, Q8N138, Q5XJR6, Q0VD15, Q9CQZ0, Q5E972, Q5XH57, Q9P0S3, Q8JFB7, Q29RQ9, NP_054901.1 |
| Reactivity | Human |
| Predicted | Bovine, Zebrafish, Xenopus, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17363 Da |
| Antigen Region | 53-81 aa |
| Gene ID | 29095 |
|---|---|
| Other Names | ORM1-like protein 2, Adoplin-2, ORMDL2 |
| Target/Specificity | This ORML2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 amino acids from the Central region of human ORML2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ORML2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ORMDL2 |
|---|---|
| Function | Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Negative regulator of sphingolipid synthesis.
References
Hjelmqvist, L., et al. Genome Biol. 3 (6), RESEARCH0027 (2002) :
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$ 365.00
$ 140.00
Cat# AP10815c
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