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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SYNE3 Antibody (C-term)   

SYNE3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SYNE3 Antibody  (C-term) AP10823b
    SYNE3 Antibody (C-term) (Cat. #AP10823b) western blot analysis in mouse spleen cell line lysates (35ug/lane).This demonstrates the SYNE3 antibody detected the SYNE3 protein (arrow).
  • IHC-P - SYNE3 Antibody  (C-term) AP10823b
    SYNE3 antibody (C-term) (Cat. #AP10823b) immunohistochemistry analysis in formalin fixed and paraffin embedded human hodgkin lymphoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SYNE3 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q6ZMZ3
Other Accession NP_689805.3
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 112216 Da
Antigen Region 852-880 aa
Additional Information
Gene ID 161176
Other Names Nesprin-3, Nuclear envelope spectrin repeat protein 3, SYNE3, C14orf49
Target/Specificity This SYNE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 852-880 amino acids from the C-terminal region of human SYNE3.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSYNE3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYNE3
Synonyms C14orf49
Function As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Cellular Location Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum
Tissue Location Expressed in aortic endothelial cells (at protein level).
Research Areas
Citations (0)

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Background

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.

References

Nery, F.C., et al. J. Cell. Sci. 121 (PT 20), 3476-3486 (2008) :
Stewart-Hutchinson, P.J., et al. Exp. Cell Res. 314(8):1892-1905(2008)
Wilhelmsen, K., et al. J. Cell Biol. 171(5):799-810(2005)
Heilig, R., et al. Nature 421(6923):601-607(2003)

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Cat# AP10823b
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(40 western blots)
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