|Application ||IHC-P, WB, E|
|Other Accession||Q9NNX9, Q9H322, NP_038480.2|
|Calculated MW||22289 Da|
|Antigen Region||1-30 aa|
|Other Names||Variable charge X-linked protein 1, Variable charge protein on X with ten repeats, VCX-10r, Variably charged protein X-B1, VCX-B1, VCX, VCX1, VCX10R, VCXB1|
|Target/Specificity||This VCX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human VCX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VCX1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||VCX1, VCX10R, VCXB1|
|Function||May mediate a process in spermatogenesis or may play a role in sex ratio distortion.|
|Tissue Location||Expressed exclusively in testis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.
Hansen, M.A., et al. Mol. Reprod. Dev. 75(2):219-229(2008)
Sy, S.M., et al. Lung Cancer 41(1):91-99(2003)
Zou, S.W., et al. Cell Res. 13(3):171-177(2003)
Fukami, M., et al. Am. J. Hum. Genet. 67(3):563-573(2000)
Lahn, B.T., et al. Hum. Mol. Genet. 9(2):311-319(2000)
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