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WDSOF1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9NV06 |
| Other Accession | NP_056235.3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51402 Da |
| Antigen Region | 369-398 aa |
| Gene ID | 25879 |
|---|---|
| Other Names | DDB1- and CUL4-associated factor 13, WD repeat and SOF domain-containing protein 1, DCAF13, WDSOF1 |
| Target/Specificity | This WDSOF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-398 amino acids from the C-terminal region of human WDSOF1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | WDSOF1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DCAF13 (HGNC:24535) |
|---|---|
| Synonyms | WDSOF1 |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome (PubMed:34516797). Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition (PubMed:30283081). |
| Cellular Location | Nucleus, nucleolus. Note=In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component |
| Tissue Location | Expressed in the endometrium during decidualization. Expression is down-regulated in preeclampsia decidual tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
References
Urano, T., et al. Bone 47(3):636-642(2010)
Jin, J., et al. Mol. Cell 23(5):709-721(2006)
Andersen, J.S., et al. Curr. Biol. 12(1):1-11(2002)
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