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PMAT(Slc29a4) Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8R139 |
| Other Accession | Q7RTT9 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58099 Da |
| Antigen Region | 452-481 aa |
| Gene ID | 243328 |
|---|---|
| Other Names | Equilibrative nucleoside transporter 4, Solute carrier family 29 member 4, Slc29a4, Ent4 |
| Target/Specificity | This PMAT(Slc29a4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 452-481 amino acids of mouse PMAT(Slc29a4). |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PMAT(Slc29a4) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Slc29a4 {ECO:0000312|MGI:MGI:2385330} |
|---|---|
| Function | Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:16873718, PubMed:23255610). Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (By similarity). Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (By similarity). Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure (PubMed:16873718). Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system (PubMed:23255610). Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (PubMed:23255610). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (PubMed:16873718). May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney (PubMed:23255610). Also transports adenine and guanidine (PubMed:16873718). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q7RTT9}; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Localized to the apical blood-cerebrospinal fluid(CSF)-facing membrane of the choroid plexus epithelium |
| Tissue Location | Expressed in heart (PubMed:16873718). Expressed in choroid plexus (PubMed:23255610). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PMAT(Slc29a4) is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the re-uptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium.
References
Barnes,K., Circ. Res. 99 (5), 510-519 (2006)
Engel,K., J. Biol. Chem. 279 (48), 50042-50049 (2004)
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