|Application ||WB, FC, E|
|Calculated MW||111693 Da|
|Antigen Region||67-96 aa|
|Other Names||Potassium voltage-gated channel subfamily H member 4, Brain-specific eag-like channel 2, BEC2, Ether-a-go-go-like potassium channel 1, ELK channel 1, ELK1, Voltage-gated potassium channel subunit Kv123, KCNH4|
|Target/Specificity||This KCNH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human KCNH4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNH4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate nucleus, and at lower levels in cerebral cortex, occipital and hippocampus|
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Provided below are standard protocols that you may find useful for product applications.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Zou, A., et al. Am. J. Physiol., Cell Physiol. 285 (6), C1356-C1366 (2003) :
Miyake, A., et al. J. Biol. Chem. 274(35):25018-25025(1999)
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