|Application ||WB, IHC-P, E|
|Calculated MW||10982 Da|
|Antigen Region||54-83 aa|
|Other Names||Late cornified envelope protein 1A, Late envelope protein 1, LCE1A, LEP1|
|Target/Specificity||This LCE1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 amino acids from the C-terminal region of human LCE1A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LCE1A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Precursors of the cornified envelope of the stratum corneum.|
|Tissue Location||Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.|
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Provided below are standard protocols that you may find useful for product applications.
LCE1A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these genes are expressed relatively late during fetal assembly of the skin cornified envelope (Jackson et al., 2005 [PubMed 15854049]). For further information on the LCE gene cluster, see GENE FAMILY below.
Jackson, B., et al. J. Invest. Dermatol. 124(5):1062-1070(2005)
Marshall, D., et al. Proc. Natl. Acad. Sci. U.S.A. 98(23):13031-13036(2001)
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