|Application ||WB, E|
|Calculated MW||30660 Da|
|Antigen Region||185-213 aa|
|Other Names||Seven in absentia homolog 3, Siah-3, SIAH3|
|Target/Specificity||This SIAH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the C-terminal region of human SIAH3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SIAH3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of PARK2 translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PARK2 targeting to dysfunctional depolarized mitochondria.|
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Provided below are standard protocols that you may find useful for product applications.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
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