|Application ||WB, E|
|Antigen Region||100-128 aa|
|Other Names||39S ribosomal protein L51, mitochondrial, L51mt, MRP-L51, bMRP-64, bMRP64, MRPL51, MRP64|
|Target/Specificity||This RM51 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-128 amino acids from the C-terminal region of human RM51.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RM51 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion EMBL; AB049959; BAB41012.1; -; mRNA EMBL; AF212248; AAK14931.1; -; mRNA EMBL; AF151075; AAF36161.1; -; mRNA EMBL; BC000191; AAH00191.1; -; mRNA EMBL; BC014329; AAH14329.1; -; mRNA EMBL; AB051355; BAB54944.1; -; Genomic_DNA CCDS; CCDS8547.1; - RefSeq; NP_057581.2; NM_016497.3 UniGene; Hs.55847; - PDB; 3J7Y; EM; 3.40 A; i=1-128 PDB; 3J9M; EM; 3.50 A; i=1-128 PDBsum; 3J7Y; - PDBsum; 3J9M; - ProteinModelPortal; Q4U2R6; - SMR; Q4U2R6; - BioGrid; 119414; 31 IntAct; Q4U2R6; 4 MINT; MINT-6775055; - STRING; 9606.ENSP00000229238; - BioMuta; MRPL51; - DMDM; 74762954; - EPD; Q4U2R6; - MaxQB; Q4U2R6; - PaxDb; Q4U2R6; - PeptideAtlas; Q4U2R6; - PRIDE; Q4U2R6; - TopDownProteomics; Q4U2R6; - Ensembl; ENST00000229238; ENSP00000229238; ENSG00000111639 GeneID; 51258; - KEGG; hsa:51258; - UCSC; uc001qom.3; human CTD; 51258; - GeneCards; MRPL51; - HGNC; HGNC:14044; MRPL51 HPA; HPA039923; - MIM; 611855; gene neXtProt; NX_Q4U2R6; - OpenTargets; ENSG00000111639; - PharmGKB; PA30984; - eggNOG; KOG4045; Eukaryota eggNOG; ENOG4111M24; LUCA GeneTree; ENSGT00390000018821; - HOGENOM; HOG000154145; - HOVERGEN; HBG093901; - InParanoid; Q4U2R6; - KO; K17432; - OMA; FNRHGKY; - OrthoDB; EOG091G0V79; - PhylomeDB; Q4U2R6; - TreeFam; TF106130; - Reactome; R-HSA-5368286; Mitochondrial translation initiation Reactome; R-HSA-5389840; Mitochondrial translation elongation Reactome; R-HSA-5419276; Mitochondrial translation termination ChiTaRS; MRPL51; human GenomeRNAi; 51258; - PRO; PR:Q4U2R6; - Proteomes; UP000005640; Chromosome 12 Bgee; ENSG00000111639; - CleanEx; HS_MRPL51; - ExpressionAtlas; Q4U2R6; baseline and differential Genevisible; Q4U2R6; HS GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome GO; GO:0005762; C:mitochondrial large ribosomal subunit; IDA:UniProtKB GO; GO:0005761; C:mitochondrial ribosome; IDA:UniProtKB GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB GO; GO:0070125; P:mitochondrial translational elongation; TAS:Reactome GO; GO:0070126; P:mitochondrial translational termination; TAS:Reactome GO; GO:0006412; P:translation; ISS:UniProtKB InterPro; IPR019373; Ribosomal_L51_mit Pfam; PF10244; MRP-L51; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide TRANSIT 1 31 Mitochondrion. CHAIN 32 128 39S ribosomal protein L51, mitochondrial /FTId=PRO_0000273082 VARIANT 102 102 M -> I (in dbSNP:rs9526) /FTId=VAR_030079 CONFLICT 79 79 W -> R (in Ref. 3; AAF36161) SEQUENCE 128 AA; 15095 MW; 9DB4720D5B387A5D CRC64; MAGNLLSGAG RRLWDWVPLA CRSFSLGVPR LIGIRLTLPP PKVVDRWNEK RAMFGVYDNI GILGNFEKHP KELIRGPIWL RGWKGNELQR CIRKRKMVGS RMFADDLHNL NKRIRYLYKH FNRHGKFR|
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Provided below are standard protocols that you may find useful for product applications.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q.
Zhang, Z., et al. Genomics 81(5):468-480(2003)
Koc, E.C., et al. J. Biol. Chem. 276(47):43958-43969(2001)
Kenmochi, N., et al. Genomics 77 (1-2), 65-70 (2001) :
Suzuki, T., et al. J. Biol. Chem. 276(35):33181-33195(2001)
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