|Application ||WB, IHC-P, FC, E|
|Other Accession||NP_001129582.1, NP_001129584.1|
|Calculated MW||49736 Da|
|Antigen Region||162-191 aa|
|Other Names||Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p20, Caspase-5 subunit p10, CASP5, ICH3|
|Target/Specificity||This CASP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the Central region of human CASP5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CASP5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediator of programmed cell death (apoptosis).|
|Tissue Location||Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
Ulybina, Y.M., et al. Exp. Gerontol. 45(9):726-729(2010)
Notaridou, M., et al. Int. J. Cancer (2010) In press :
Kim, M.S., et al. APMIS 118(4):308-312(2010)
Liang, X.S., et al. Br. J. Haematol. 146(4):418-423(2009)
Eckhart, L., et al. Biochem. Biophys. Res. Commun. 348(2):682-688(2006)
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