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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CDKN1C Antibody (N-term)   

CDKN1C Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • IF - CDKN1C Antibody (N-term) AP10945A
    Fluorescent image of A549 cell stained with CDKN1C Antibody (N-term)(Cat#AP10945a).A549 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CDKN1C primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃).CDKN1C immunoreactivity is localized to Nucleus significantly.
  • WB - CDKN1C Antibody (N-term) AP10945A
    CDKN1C Antibody (N-term) (Cat. #AP10945a) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CDKN1C antibody detected the CDKN1C protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49918
Other Accession NP_001116102.1, NP_000067.1, NP_001116103.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 32177 Da
Antigen Region 34-64 aa
Additional Information
Gene ID 1028
Other Names Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2, CDKN1C, KIP2
Target/Specificity This CDKN1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-64 amino acids from the N-terminal region of human CDKN1C.
Dilution IF~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDKN1C Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIP2
Function Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.
Cellular Location Nucleus.
Tissue Location Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
Research Areas
Citations (0)

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This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.


O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)
Madhavan, J., et al. Ophthalmic Genet. 31(3):141-146(2010)
Romanelli, V., et al. Am. J. Med. Genet. A 152A (6), 1390-1397 (2010) :
Hoffner, L., et al. J Reprod Med 55 (5-6), 219-228 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :

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$ 295.00
$ 99.00
Cat# AP10945A
(40 western blots)
Availability: In Stock
Bulk Size
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