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CENTG1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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Ordering Information
Catalog # SizeAvailability Price  
AP10947b 400 µl
(40 western blots)
In Stock
$ 265.00email & fax$ 251.75online
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AP10947b-ev 80 µl
(8 western blots)
In Stock
$ 95.00email & fax$ 90.25online
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  • Specification
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CENTG1 Antibody (C-term) - Product info

Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary AccessionQ99490
Other AccessionQ8CGU4, Q3UHD9, NP_001116244.1, NP_055585.1
ReactivityHuman, Mouse
PredictedRat
Isotype Rabbit Ig
Calculated MW 124674 Da

CENTG1 Antibody (C-term) - Additional info

Gene ID 116986
Other Names
AGAP2; CENTG1; KIAA0167; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; Centaurin-gamma-1; GTP-binding and GTPase-activating protein 2; Phosphatidylinositol 3-kinase enhancer
Target/Specificity
This CENTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1.
Dilution
WB~~1:1000
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
CENTG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.

CENTG1 Antibody (C-term) - Protein Information

Name AGAP2
Synonyms CENTG1, KIAA0167
Function
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Cellular Location
Isoform 1: Cytoplasm. Nucleus.
Tissue Location
Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart

CENTG1 Antibody (C-term) - Related products

BP10947b: CENTG1 Antibody (C-term) Blocking Peptides

CENTG1 Antibody (C-term) - Research Areas

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BACKGROUND

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

REFERENCES

Shiba, Y., et al. J. Cell. Sci. 123 (PT 14), 2381-2390 (2010) :
Zhu, Y., et al. J. Biol. Chem. 284(20):13489-13496(2009)
Cai, Y., et al. Cancer Res. 69(3):819-827(2009)
Tang, X., et al. Nat. Cell Biol. 10(6):698-706(2008)
Liu, R., et al. Proc. Natl. Acad. Sci. U.S.A. 105(21):7570-7575(2008)