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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CENTG1 Antibody (C-term)   

CENTG1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CENTG1 Antibody (C-term) AP10947b
    CENTG1 Antibody (C-term) (Cat. #AP10947b) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the CENTG1 antibody detected the CENTG1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q99490
Other Accession Q8CGU4, Q3UHD9, NP_001116244.1, NP_055585.1
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 124674 Da
Antigen Region 850-877 aa
Additional Information
Gene ID 116986
Other Names Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, AGAP-2, Centaurin-gamma-1, Cnt-g1, GTP-binding and GTPase-activating protein 2, GGAP2, Phosphatidylinositol 3-kinase enhancer, PIKE, AGAP2, CENTG1, KIAA0167
Target/Specificity This CENTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Protein Information
Name AGAP2
Synonyms CENTG1, KIAA0167
Function GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Cellular Location Isoform 1: Cytoplasm. Nucleus.
Tissue Location Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart
Research Areas
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Background

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

References

Shiba, Y., et al. J. Cell. Sci. 123 (PT 14), 2381-2390 (2010) :
Zhu, Y., et al. J. Biol. Chem. 284(20):13489-13496(2009)
Cai, Y., et al. Cancer Res. 69(3):819-827(2009)
Tang, X., et al. Nat. Cell Biol. 10(6):698-706(2008)
Liu, R., et al. Proc. Natl. Acad. Sci. U.S.A. 105(21):7570-7575(2008)

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$ 265.00
$ 95.00
Cat# AP10947b
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Quantity:
(40 western blots)
Availability: In Stock
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