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CENTG1 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP10947b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP10947b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
CENTG1 Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q99490 |
| Other Accession | Q8CGU4, Q3UHD9, NP_001116244.1, NP_055585.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 124674 Da |
CENTG1 Antibody (C-term) - Additional info | |
| Gene ID 116986 | |
| Other Names AGAP2; CENTG1; KIAA0167; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; Centaurin-gamma-1; GTP-binding and GTPase-activating protein 2; Phosphatidylinositol 3-kinase enhancer | |
| Target/Specificity This CENTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CENTG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CENTG1 Antibody (C-term) - Protein Information | |
| Name AGAP2 | |
| Synonyms CENTG1, KIAA0167 | |
| Function GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion | |
| Cellular Location Isoform 1: Cytoplasm. Nucleus. | |
| Tissue Location Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart | |
CENTG1 Antibody (C-term) - Related products
CENTG1 Antibody (C-term) - Application data
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CENTG1 Antibody (C-term) (Cat. #AP10947b) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the CENTG1 antibody detected the CENTG1 protein (arrow).
CENTG1 Antibody (C-term) - Research Areas
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BACKGROUND
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
REFERENCES
Shiba, Y., et al. J. Cell. Sci. 123 (PT 14), 2381-2390 (2010) : Zhu, Y., et al. J. Biol. Chem. 284(20):13489-13496(2009) Cai, Y., et al. Cancer Res. 69(3):819-827(2009) Tang, X., et al. Nat. Cell Biol. 10(6):698-706(2008) Liu, R., et al. Proc. Natl. Acad. Sci. U.S.A. 105(21):7570-7575(2008)
