|Application ||WB, IHC-P, FC, E|
|Other Accession||Q9CWK3, NP_006101.1|
|Calculated MW||37646 Da|
|Antigen Region||24-52 aa|
|Other Names||CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein 2, CD2 tail-binding protein 2, U5 snRNP 52K protein, U5-52K, CD2BP2, KIAA1178|
|Target/Specificity||This CD2BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human CD2BP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD2BP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly nuclear|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.
Heinze, M., et al. Int. Immunol. 19(11):1313-1318(2007)
Nielsen, T.K., et al. J. Mol. Biol. 369(4):902-908(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Al-Dhaheri, M.H., et al. Steroids 71 (11-12), 966-978 (2006) :
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