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CD2BP2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, IHC-P, E |
|---|---|
| Primary Accession | O95400 |
| Other Accession | Q9CWK3, NP_006101.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37646 Da |
| Antigen Region | 24-52 aa |
| Gene ID | 10421 |
|---|---|
| Other Names | CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein 2, CD2 tail-binding protein 2, U5 snRNP 52K protein, U5-52K, CD2BP2, KIAA1178 |
| Target/Specificity | This CD2BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human CD2BP2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD2BP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD2BP2 |
|---|---|
| Synonyms | KIAA1178 |
| Function | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. |
| Cellular Location | Cytoplasm. Nucleus. Note=Predominantly nuclear. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.
References
Heinze, M., et al. Int. Immunol. 19(11):1313-1318(2007)
Nielsen, T.K., et al. J. Mol. Biol. 369(4):902-908(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Al-Dhaheri, M.H., et al. Steroids 71 (11-12), 966-978 (2006) :
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