|Application ||WB, FC, E|
|Calculated MW||56617 Da|
|Antigen Region||420-449 aa|
|Other Names||Histone-lysine N-methyltransferase SMYD1, SET and MYND domain-containing protein 1, SMYD1|
|Target/Specificity||This SMYD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 420-449 amino acids from the C-terminal region of human SMYD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMYD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expression seems mostly restricted to heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis (By similarity).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Yang, J., et al. J. Mol. Biol. 386(4):938-950(2009)
Sims, R.J. III, et al. J. Biol. Chem. 277(29):26524-26529(2002)
Gottlieb, P.D., et al. Nat. Genet. 31(1):25-32(2002)
Srivastava, D., et al. Cold Spring Harb. Symp. Quant. Biol. 67, 121-125 (2002) :
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