|Application ||WB, IHC-P, E|
|Other Accession||NP_001253.1, NP_523240.1|
|Calculated MW||18127 Da|
|Antigen Region||113-139 aa|
|Other Names||Cyclin-dependent kinase 4 inhibitor C, Cyclin-dependent kinase 6 inhibitor, p18-INK4c, p18-INK6, CDKN2C, CDKN6|
|Target/Specificity||This CDKN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-139 amino acids from the C-terminal region of human CDKN2C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDKN2C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.|
|Tissue Location||Highest levels found in skeletal muscle. Also found in pancreas and heart|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
Stratakis, C., et al. Clin. Genet. 78(5):457-463(2010)
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)
Eguchi, T., et al. Mol. Cancer Ther. 8(6):1460-1472(2009)
Pei, X.H., et al. Cancer Cell 15(5):389-401(2009)
Hossain, M.G., et al. Endocr. Pathol. 20(2):114-121(2009)
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