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IL18 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - IL18 Antibody (Center) AP10957b
    Western blot analysis of IL18 (arrow) using rabbit polyclonal IL18 Antibody (Center) (Cat. #AP10957b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the IL18 gene (Lane 2) .
  • WB - IL18 Antibody (Center) AP10957b
    IL18 Antibody (Center) (Cat. #AP10957b) western blot analysis in MDA-MB468 cell line lysates (35ug/lane).This demonstrates the IL18 antibody detected the IL18 protein (arrow).
  • IHC-P - IL18 Antibody (Center) AP10957b
    IL18 antibody (Center) (Cat. #AP10957b) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IL18 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • IF - IL18 Antibody (Center) AP10957b
    Confocal immunofluorescent analysis of IL18 Antibody (Center)(Cat. #AP10957b) with Hela cell followed by Alexa Fluor搴?488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14116
Other Accession NP_001553.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22326 Da
Antigen Region 44-73 aa
Additional Information
Gene ID 3606
Other Names Interleukin-18, IL-18, Iboctadekin, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, IL18, IGIF, IL1F4
Target/Specificity This IL18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-73 amino acids from the Central region of human IL18.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL18 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL18
Synonyms IGIF, IL1F4
Function Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
Cellular Location Secreted.
Research Areas
Citations (0)

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The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.


Hernesniemi, J.A., et al. Eur. J. Clin. Invest. 40(11):994-1001(2010)
Hartford, M., et al. Arterioscler. Thromb. Vasc. Biol. 30(10):2039-2046(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Franchim, C.S., et al. Hypertens Pregnancy (2010) In press :
Ayaz, L., et al. Fertil. Steril. (2010) In press :

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Cat# AP10957b
(40 western blots)
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