|Application ||WB, IHC-P, IF, FC, E|
|Other Accession||P61261, NP_005209.1|
|Calculated MW||7420 Da|
|Antigen Region||11-36 aa|
|Other Names||Beta-defensin 1, BD-1, hBD-1, Defensin, beta 1, DEFB1, BD1, HBD1|
|Target/Specificity||This DEFB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-36 amino acids from the N-terminal region of human DEFB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DEFB1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).|
|Cellular Location||Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles (PubMed:23938203)|
|Tissue Location||Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) : Garreis, F., et al. Histochem. Cell Biol. 134(1):59-73(2010) Segat, L., et al. Int. J. Dermatol. 49(6):653-657(2010) Tiszlavicz, Z., et al. Pancreatology 10(4):483-490(2010) Yin, L., et al. BMC Immunol. 11, 37 (2010) :
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