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ITIH5 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ITIH5 Antibody (C-term) AP10965b
    ITIH5 Antibody (C-term) (Cat. #AP10965b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the ITIH5 antibody detected the ITIH5 protein (arrow).
  • IHC-P - ITIH5 Antibody (C-term) AP10965b
    ITIH5 Antibody (C-term) (Cat. #AP10965b) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ITIH5 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86UX2
Other Accession NP_085046.4, NP_116206.3, NP_001001851.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 104576 Da
Antigen Region 578-606 aa
Additional Information
Gene ID 80760
Other Names Inter-alpha-trypsin inhibitor heavy chain H5, ITI heavy chain H5, ITI-HC5, Inter-alpha-inhibitor heavy chain 5, ITIH5, KIAA1953
Target/Specificity This ITIH5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 578-606 amino acids from the C-terminal region of human ITIH5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsITIH5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITIH5
Synonyms KIAA1953
Function May act as a tumor suppressor.
Cellular Location Secreted.
Tissue Location Abundantly expressed in placenta. Less abundant expression in mammary gland and ovary. Expression is barely detectable levels in all other tissues tested
Research Areas
Citations (0)

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This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants.


Pita, J.M., et al. Br. J. Cancer 101(10):1782-1791(2009)
Veeck, J., et al. Pathologe 29 SUPPL 2, 338-346 (2008) :
Veeck, J., et al. Oncogene 27(6):865-876(2008)
Hamm, A., et al. BMC Cancer 8, 25 (2008) :
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)

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Cat# AP10965b
(40 western blots)
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