|Application ||WB, E|
|Other Accession||Q99PV8, NP_612808.1, NP_075049.1|
|Calculated MW||95519 Da|
|Antigen Region||307-334 aa|
|Other Names||B-cell lymphoma/leukemia 11B, BCL-11B, B-cell CLL/lymphoma 11B, COUP-TF-interacting protein 2, Radiation-induced tumor suppressor gene 1 protein, hRit1, BCL11B, CTIP2, RIT1|
|Target/Specificity||This BCL11B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-334 amino acids from the Central region of human BCL11B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCL11B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity).|
|Tissue Location||Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.
Ganguli-Indra, G., et al. Exp. Dermatol. 18(11):994-996(2009)
Cherrier, T., et al. Oncogene 28(38):3380-3389(2009)
Ganguli-Indra, G., et al. PLoS ONE 4 (4), E5367 (2009) :
Cismasiu, V.B., et al. Virology 380(2):173-181(2008)
Desplats, P.A., et al. Neurobiol. Dis. 31(3):298-308(2008)
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