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ASCL2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ASCL2 Antibody (N-term) AP10976A
    ASCL2 Antibody (N-term) (Cat. #AP10976a) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the ASCL2 antibody detected the ASCL2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q99929
Other Accession Q90259, P19360, O35885, Q2EGB9, Q06234, P19359, Q02067, P50553, NP_005161.1
Reactivity Human, Mouse
Predicted Rat, Xenopus, Zebrafish
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 38-65 aa
Additional Information
Other Names Achaete-scute homolog 2, ASH-2, hASH2, Class A basic helix-loop-helix protein 45, bHLHa45, Mash2, ASCL2, BHLHA45, HASH2
Target/Specificity This ASCL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the N-terminal region of human ASCL2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsASCL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASCL2
Synonyms BHLHA45, HASH2
Function AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:11440538}
Tissue Location Expressed specifically in the extravillous trophoblasts of the developing placenta EMBL; U77629; AAB86993.1; -; Genomic_DNA EMBL; AF442769; AAL35362.1; -; Genomic_DNA EMBL; BC057801; AAH57801.2; -; mRNA EMBL; BC136561; AAI36562.1; -; mRNA EMBL; BC136567; AAI36568.1; -; mRNA EMBL; S82817; AAB39362.1; -; Genomic_DNA CCDS; CCDS7732.1; - RefSeq; NP_005161.1; NM_005170.2 UniGene; Hs.152475; - ProteinModelPortal; Q99929; - SMR; Q99929; - BioGrid; 106922; 7 STRING; 9606.ENSP00000332293; - iPTMnet; Q99929; - PhosphoSitePlus; Q99929; - BioMuta; ASCL2; - DMDM; 12644476; - PaxDb; Q99929; - PeptideAtlas; Q99929; - PRIDE; Q99929; - ProteomicsDB; 78523; - Ensembl; ENST00000331289; ENSP00000332293; ENSG00000183734 GeneID; 430; - KEGG; hsa:430; - UCSC; uc001lvu.4; human CTD; 430; - DisGeNET; 430; - EuPathDB; HostDB:ENSG00000183734.4; - GeneCards; ASCL2; - HGNC; HGNC:739; ASCL2 MIM; 601886; gene neXtProt; NX_Q99929; - OpenTargets; ENSG00000183734; - PharmGKB; PA25039; - eggNOG; ENOG410ISUZ; Eukaryota eggNOG; ENOG410Y0IE; LUCA GeneTree; ENSGT00530000063321; - HOGENOM; HOG000013056; - HOVERGEN; HBG050590; - InParanoid; Q99929; - KO; K09067; - OMA; ACPRESC; - OrthoDB; EOG091G0OB6; - PhylomeDB; Q99929; - TreeFam; TF322889; - GeneWiki; ASCL2; - GenomeRNAi; 430; - PRO; PR:Q99929; - Proteomes; UP000005640; Chromosome 11 Bgee; ENSG00000183734; - CleanEx; HS_ASCL2; - Genevisible; Q99929; HS GO; GO:0005737; C:cytoplasm; IDA:UniProtKB GO; GO:0005634; C:nucleus; IDA:UniProtKB GO; GO:0090575; C:RNA polymerase II transcription factor complex; IBA:GO_Central GO; GO:0003700; F:DNA binding transcription factor activity; NAS:UniProtKB GO; GO:0070888; F:E-box binding; IDA:UniProtKB GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:NTNU_SB GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:NTNU_SB GO; GO:0010626; P:negative regulation of Schwann cell proliferation; IEA:Ensembl GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB GO; GO:0001890; P:placenta development; NAS:UniProtKB GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB GO; GO:0001666; P:response to hypoxia; IEP:UniProtKB GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl GO; GO:0060708; P:spongiotrophoblast differentiation; IEA:Ensembl GO; GO:0060712; P:spongiotrophoblast layer development; IEP:UniProtKB GO; GO:0006351; P:transcription, DNA-templated; IDA:UniProtKB CDD; cd00083; HLH; 1 Gene3D; 4.10.280.10; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf InterPro; IPR015660; MASH1/Ascl1a-like PANTHER; PTHR13935; PTHR13935; 1 Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 1: Evidence at protein level; Complete proteome; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome CHAIN 1 193 Achaete-scute homolog 2 /FTId=PRO_0000127130 DOMAIN 50 102 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} COMPBIAS 36 39 Poly-Arg SEQUENCE 193 AA; 20185 MW; E59A71342E6D46C8 CRC64; MDGGTLPRSA PPAPPVPVGC AARRRPASPE LLRCSRRRRP ATAETGGGAA AVARRNERER NRVKLVNLGF QALRQHVPHG GASKKLSKVE TLRSAVEYIR ALQRLLAEHD AVRNALAGGL RPQAVRPSAP RGPPGTTPVA ASPSRASSSP GRGGSSEPGS PRSAYSSDDS GCEGALSPAE RELLDFSSWL GGY
Research Areas
Citations (0)

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Background

This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

References

Stange, D.E., et al. Gut 59(9):1236-1244(2010)
Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009)
Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009)
Shahib, M.N., et al. J Reprod Med 51(11):892-896(2006)
Jubb, A.M., et al. Oncogene 25(24):3445-3457(2006)

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Cat# AP10976A
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