|Application ||WB, IHC-P, E|
|Calculated MW||46289 Da|
|Antigen Region||392-419 aa|
|Other Names||WAS/WASL-interacting protein family member 2, WASP-interacting protein-related protein, WIP- and CR16-homologous protein, WIP-related protein, WIPF2, WICH, WIRE|
|Target/Specificity||This WIPF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 392-419 amino acids from the C-terminal region of human WIPF2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WIPF2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.|
|Cellular Location||Cytoplasm, cytoskeleton Note=Localized to stress fibers and bundles of actin filaments|
|Tissue Location||Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Salazar, M.A., et al. J. Biol. Chem. 278(49):49031-49043(2003)
Aspenstrom, P. Exp. Cell Res. 279(1):21-33(2002)
Kato, M., et al. Biochem. Biophys. Res. Commun. 291(1):41-47(2002)
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