|Application ||WB, IHC-P, FC, E|
|Other Accession||Q9R1R4, A6QLE1, NP_055105.2|
|Calculated MW||123586 Da|
|Antigen Region||807-835 aa|
|Other Names||Tudor domain-containing protein 7, PCTAIRE2-binding protein, Tudor repeat associator with PCTAIRE-2, Trap, TDRD7, PCTAIRE2BP|
|Target/Specificity||This TDRD7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 807-835 amino acids from the C-terminal region of human TDRD7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TDRD7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.|
|Cellular Location||Cytoplasm. Note=Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
TDRD7, also known as Tudor domain containing protein 7, is a component of chromatoid bodies in spermatids (named processing bodies or P-bodies in somatic cells). It is found in a mRNP complex together with TDRD1, TDRD6 and DDX4. It is also found in a complex with CABLES1, PCTK2 and PIWIL1. TDRD7 has been shown to interact with histone H3 tri-methylated at K9 in vitro.
Lim, J., et al. Cell 125(4):801-814(2006)
Conte, N., et al. Oncogene 22(50):8102-8116(2003)
Lauffart, B., et al. Biochem. J. 363 (PT 1), 195-200 (2002) :
Yamochi, T., et al. Biochem. Biophys. Res. Commun. 286(5):1045-1050(2001)
Hirose, T., et al. Eur. J. Biochem. 267(7):2113-2121(2000)
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