|Application ||WB, IHC-P, E|
|Other Accession||NP_055554.1, NP_001070908.1, NP_001070909.1|
|Calculated MW||106122 Da|
|Antigen Region||658-687 aa|
|Other Names||Bcl-2-associated transcription factor 1, Btf, BCLAF1, BTF, KIAA0164|
|Target/Specificity||This BCLAF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 658-687 amino acids from the C-terminal region of human BCLAF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCLAF1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus speckle. Nucleus, nucleoplasm|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Sarras, H., et al. ScientificWorldJournal 10, 1450-1461 (2010) :
Renert, A.F., et al. J. Proteome Res. 8(10):4810-4822(2009)
Liu, H., et al. Mol. Cell. Biol. 27(24):8480-8491(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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