|Application ||WB, IHC-P, E|
|Calculated MW||20350 Da|
|Antigen Region||12-40 aa|
|Other Names||NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3, NDUFAF3, C3orf60|
|Target/Specificity||This NDUF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human NDUF3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NDUF3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|
|Cellular Location||Nucleus. Mitochondrion inner membrane|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a mitochondrial complex I assembly protein that interacts with complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency, a fatal neonatal disorder of the oxidative phosphorylation system. Alternatively spliced transcript variants encoding different isoforms have been identified.
Saada, A., et al. Am. J. Hum. Genet. 84(6):718-727(2009)
Hammami-Hamza, S., et al. Int. J. Dev. Biol. 47(1):71-76(2003)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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