|Application ||WB, E|
|Calculated MW||17342 Da|
|Antigen Region||118-146 aa|
|Other Names||Protein FAM162A, E2-induced gene 5 protein, Growth and transformation-dependent protein, HGTD-P, FAM162A, C3orf28, E2IG5|
|Target/Specificity||This F162A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-146 amino acids from the C-terminal region of human F162A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||F162A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.|
|Cellular Location||Membrane; Single-pass membrane protein. Mitochondrion|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)
Qu, Y., et al. Stroke 40(8):2843-2848(2009)
Cho, Y.E., et al. Hum. Pathol. 40(7):975-981(2009)
Kim, J.Y., et al. FEBS Lett. 580(13):3270-3275(2006)
Lee, M.J., et al. Mol. Cell. Biol. 24(9):3918-3927(2004)
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