|Application ||WB, IHC-P, E|
|Other Accession||Q8BHN0, A5PJZ2, NP_640338.2|
|Calculated MW||41053 Da|
|Antigen Region||215-244 aa|
|Other Names||Protein phosphatase 1L, Protein phosphatase 1-like, Protein phosphatase 2C isoform epsilon, PP2C-epsilon, PPM1L, PP2CE|
|Target/Specificity||This PPM1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the C-terminal region of human PPM1L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPM1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular stimuli (Jin et al., 2004 [PubMed 15560375]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Thean, L.F., et al. Genes Chromosomes Cancer 49(2):99-106(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Saito, S., et al. J. Biol. Chem. 283(10):6584-6593(2008)
Saito, J., et al. Biochem. J. 405(3):591-596(2007)
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