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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PPM1L Antibody (C-term)   

PPM1L Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PPM1L Antibody  (C-term) AP11001b
    PPM1L Antibody (C-term) (Cat. #AP11001b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the PPM1L antibody detected the PPM1L protein (arrow).
  • IHC-P - PPM1L Antibody  (C-term) AP11001b
    PPM1L antibody (C-term) (Cat. #AP11001b) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PPM1L antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5SGD2
Other Accession Q8BHN0, A5PJZ2, NP_640338.2
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41053 Da
Antigen Region 215-244 aa
Additional Information
Gene ID 151742
Other Names Protein phosphatase 1L, Protein phosphatase 1-like, Protein phosphatase 2C isoform epsilon, PP2C-epsilon, PPM1L, PP2CE
Target/Specificity This PPM1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the C-terminal region of human PPM1L.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPPM1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPM1L
Synonyms PP2CE
Function Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas
Research Areas
Citations (0)

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PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular stimuli (Jin et al., 2004 [PubMed 15560375]).


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Thean, L.F., et al. Genes Chromosomes Cancer 49(2):99-106(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Saito, S., et al. J. Biol. Chem. 283(10):6584-6593(2008)
Saito, J., et al. Biochem. J. 405(3):591-596(2007)

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$ 295.00
$ 99.00
Cat# AP11001b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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